Koc University Hemorheology, Hemodynamics and Vascular Biology Laboratory (HHVBL)
Hemorheology, Hemodynamics and Vascular Biology Laboratory (HHVBL) was established in 2011 with a motivation to investigate the regulation of blood flow at microcirculatory level and the role of hemorheological mechanisms in blood flow and tissue perfusion. Our research interests are mainly blood coagulation, red blood cell mechanics, and effect of alterations in these properties on in vivo hemodynamics and vascular function. Our aim is to develop novel diagnostic devices and methods for monitoring mechanical blood trauma, coagulopathies and microcirculation disorders to treat, manage, and ultimately prevent diseases. Our research primarily involves experimental platforms to understand how blood rheological changes affect organ and tissue function from cellular to macroscopic level. The HHVBL’s current experimental efforts are focused on conditions such as polycythemia, anemia and red blood cell pathologies such as malaria and sickle cell disease. The lab’s basic toolbox consists of laser-assisted optical rotational cell analyzer, myrenne erythrocyte aggregometer, photometric erythrocyte aggregometer, cell electrophoresis system, automatic hemoglobin oxygen equilibrium analyzer, hematology analyzer, and living systems isolated blood vessel perfusion system. The ongoing research projects sought in the lab are divided into different sub-topics with focus on four major areas: flow dynamics, comparative hemorheology, hemorheological and coagulation instrumentation.